Times are shown in your local time zone GMT
Ad-blocker Detected - Your browser has an ad-blocker enabled, please disable it to ensure your attendance is not impacted, such as CPD tracking (if relevant). For technical help, contact Support.
Dr Chris Lupton
Monash University
Professional Bio
PhD, Post-doctoral Researcher
Dr Christopher Lupton is a research fellow at the Monash Biomedicine Discovery Institute (BDI) and one of Australia's leading cryo-electron microscopists. He specialises in capturing an atomic resolution view of 'signalling in action' by determining the structures of key protein complexes in cell growth and cancer. He earned his PhD from Monash University in 2017 and has since gained extensive expertise in a range of electron microscopy techniques.
In 2020, he joined the Ellisdon Laboratory, where his research primarily focuses on the elucidating the structure of key oncogenes and tumour suppressor proteins in central cancer signalling pathways. Driven by his utilisation of cryo-electron microscopy, he strives to unravel intricate protein structures to reveal their biological function and mechanisms of dysregulation in disease.
Dr Lupton's ground-breaking work includes studying the cryo-EM structure of neurofibromin-1 (NF1) and P-Rex1, two key tumour-suppressor proteins. He discovered a previously unknown autoinhibitory mechanism that governs NF1's capacity to deactivate Ras, a central signalling protein in cell growth and cancer. This discovery sheds light on the elevated susceptibility to cancer associated with NF1 loss-of-function mutations and implicates their involvement in various cancer types, including melanoma, ovarian, breast, and brain cancer.
Dr Christopher Lupton is a research fellow at the Monash Biomedicine Discovery Institute (BDI) and one of Australia's leading cryo-electron microscopists. He specialises in capturing an atomic resolution view of 'signalling in action' by determining the structures of key protein complexes in cell growth and cancer. He earned his PhD from Monash University in 2017 and has since gained extensive expertise in a range of electron microscopy techniques.
In 2020, he joined the Ellisdon Laboratory, where his research primarily focuses on the elucidating the structure of key oncogenes and tumour suppressor proteins in central cancer signalling pathways. Driven by his utilisation of cryo-electron microscopy, he strives to unravel intricate protein structures to reveal their biological function and mechanisms of dysregulation in disease.
Dr Lupton's ground-breaking work includes studying the cryo-EM structure of neurofibromin-1 (NF1) and P-Rex1, two key tumour-suppressor proteins. He discovered a previously unknown autoinhibitory mechanism that governs NF1's capacity to deactivate Ras, a central signalling protein in cell growth and cancer. This discovery sheds light on the elevated susceptibility to cancer associated with NF1 loss-of-function mutations and implicates their involvement in various cancer types, including melanoma, ovarian, breast, and brain cancer.